The Santa Fe Trail ran from 1821 until 1846 (25 years). It was a two-way international commercial highway used by both Mexican and American traders. The main purpose of the Trail was mostly a trade route but saw a good share of emigrants, especially during the California Gold Rush and the Pikes Peak Gold Rush in Colorado. The length of it is over 869 miles. If you ever tried to walk all of it, it would take about 2 months. You can find the Santa Fe Trail in Missouri, Kansas, Oklahoma, Texas, New Mexico, and Colorado.
The Santa Fe Trail was used by thousands of travelers from 1821- 1880, from Missouri to Santa Fe, New Mexico. Traders would travel in wagon caravans to bring finished goods west, taking silver and mules east.